I definitely see where Steve, Blake-mun and Octavius-mun are coming from. I, too, would hope that whatever system is developed would be fair.
Admittedly, I hadn't considered that players would use something like poisons to roll the game, or cause instant character death, so I'm glad that somebody pointed it out to me.
But yes, Sophie-mun, I think something combining chemistry and botany would be neat too. Just for dorky role-playing reasons.